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CASSCF(14,13) geometry optimization of one form of vitamin B12 and models of glutathione, NADPH, FMN, or FAD shows that all forms interact with these agents by breaking Co-C or Co-O bonds and accepting one electron or significant electron density, increasing electron transfer toward the end of the reactions

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There is a lot left to understand but were hopeful we can translate these discoveries to new therapies. Several sources funded the research, including the Wilmot Cancer Institute, the American Association for Cancer Research and Breast Cancer Research Foundation, Breast Cancer Coalition of Rochester, American Cancer Society, and the National Institutes of Health